Application | Comment | Organism |
---|---|---|
medicine | targeting enoyl-ACP reductase is an attractive approach for the development of novel antibacterials | Bacillus anthracis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2-chlorobenzyl)-4-(naphthalen-1-ylmethoxy)pyridin-2(1H)-one | - |
Bacillus anthracis | |
1-(2-chlorobenzyl)-4-(naphthalen-2-ylmethoxy)pyridin-2(1H)-one | - |
Bacillus anthracis | |
1-(2-chlorobenzyl)-4-[3-(1H-imidazol-1-yl)propoxy]pyridin-2(1H)-one | - |
Bacillus anthracis | |
1-(2-chlorobenzyl)-4-[3-(1H-indol-1-yl)propoxy]pyridin-2(1H)-one | - |
Bacillus anthracis | |
1-(4-amino-2-chlorobenzyl)-4-(benzyloxy)pyridin-2(1H)-one | - |
Bacillus anthracis | |
1-benzyl-4-(benzyloxy)pyridin-2(1H)-one | - |
Bacillus anthracis | |
1-benzyl-4-hydroxypyridin-2(1H)-one | less than 30% inhibition at 0.1 mM | Bacillus anthracis | |
1-benzyl-4-[3-(9H-carbazol-9-yl)propoxy]pyridin-2(1H)-one | less than 30% inhibition at 0.1 mM | Bacillus anthracis | |
3-(2,4-dichlorophenoxy)-6-methoxypyridin-2(1H)-one | - |
Bacillus anthracis | |
3-(2-chlorophenoxy)-6-methoxypyridin-2(1H)-one | - |
Bacillus anthracis | |
3-benzyl-6-(benzyloxy)pyridin-2(1H)-one | - |
Bacillus anthracis | |
4-(benzyloxy)-1-(2-chloro-4-nitrobenzyl)pyridin-2(1H)-one | - |
Bacillus anthracis | |
4-(benzyloxy)-1-(2-chlorobenzyl)pyridin-2(1H)-one | - |
Bacillus anthracis | |
4-([[1-(2-chlorobenzyl)-2-oxo-1,2-dihydropyridin-4-yl]oxy]methyl)benzonitrile | - |
Bacillus anthracis | |
4-hydroxy-1-(4-hydroxybenzyl)pyridin-2(1H)-one | less than 30% inhibition at 0.1 mM | Bacillus anthracis | |
4-hydroxy-1-(4-methoxybenzyl)pyridin-2(1H)-one | less than 30% inhibition at 0.1 mM | Bacillus anthracis | |
4-[3-(1H-benzotriazol-1-yl)propoxy]-1-(2-chlorobenzyl)pyridin-2(1H)-one | - |
Bacillus anthracis | |
4-[3-(9H-carbazol-9-yl)propoxy]-1-(2-chlorobenzyl)pyridin-2(1H)-one | - |
Bacillus anthracis | |
4-[3-(9H-carbazol-9-yl)propoxy]-1-(4-methoxybenzyl)pyridin-2(1H)-one | - |
Bacillus anthracis | |
4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzamide | - |
Bacillus anthracis | |
4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzoic acid | - |
Bacillus anthracis | |
4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzonitrile | - |
Bacillus anthracis | |
5-(2-chlorophenoxy)-2-methoxypyridine 1-oxide | less than 30% inhibition at 0.1 mM | Bacillus anthracis | |
5-chloro-2-(2,4-dichlorophenoxy)pyridine 1-oxide | - |
Bacillus anthracis | |
6-(benzyloxy)-3-phenoxypyridin-2(1H)-one | - |
Bacillus anthracis | |
ethyl 5-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]isoxazole-3-carboxylate | less than 30% inhibition at 0.1 mM | Bacillus anthracis | |
isoniazid | - |
Bacillus anthracis | |
N-(4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorophenyl)acetamide | - |
Bacillus anthracis | |
triclosan | potent inhibitor | Bacillus anthracis | |
[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]acetonitrile | less than 30% inhibition at 0.1 mM | Bacillus anthracis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bacillus anthracis | the final step of chain elongation in the bacterial fatty acid biosynthesis is the reduction of enoyl-ACP to an acyl-ACP, catalyzed by enoyl-ACP reductase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-[acyl-carrier protein] + NAD+ | - |
Bacillus anthracis | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
additional information | the final step of chain elongation in the bacterial fatty acid biosynthesis is the reduction of enoyl-ACP to an acyl-ACP, catalyzed by enoyl-ACP reductase | Bacillus anthracis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BaENR | - |
Bacillus anthracis |
enoyl-ACP reductase | - |
Bacillus anthracis |
enoyl-acyl carrier protein reductase | - |
Bacillus anthracis |
ENR | - |
Bacillus anthracis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Bacillus anthracis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
- |
Bacillus anthracis | triclosan | |
0.0007 | - |
- |
Bacillus anthracis | 6-(benzyloxy)-3-phenoxypyridin-2(1H)-one | |
0.0007 | - |
- |
Bacillus anthracis | 3-benzyl-6-(benzyloxy)pyridin-2(1H)-one | |
0.0008 | - |
- |
Bacillus anthracis | 1-(4-amino-2-chlorobenzyl)-4-(benzyloxy)pyridin-2(1H)-one | |
0.0008 | - |
- |
Bacillus anthracis | 1-(2-chlorobenzyl)-4-[3-(1H-indol-1-yl)propoxy]pyridin-2(1H)-one | |
0.0011 | - |
- |
Bacillus anthracis | 1-(2-chlorobenzyl)-4-(naphthalen-2-ylmethoxy)pyridin-2(1H)-one | |
0.0015 | - |
- |
Bacillus anthracis | 4-(benzyloxy)-1-(2-chlorobenzyl)pyridin-2(1H)-one | |
0.0015 | - |
- |
Bacillus anthracis | 1-(2-chlorobenzyl)-4-(naphthalen-1-ylmethoxy)pyridin-2(1H)-one | |
0.0016 | - |
- |
Bacillus anthracis | 4-[3-(1H-benzotriazol-1-yl)propoxy]-1-(2-chlorobenzyl)pyridin-2(1H)-one | |
0.0018 | - |
- |
Bacillus anthracis | N-(4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorophenyl)acetamide | |
0.0027 | - |
- |
Bacillus anthracis | 4-([[1-(2-chlorobenzyl)-2-oxo-1,2-dihydropyridin-4-yl]oxy]methyl)benzonitrile | |
0.003 | - |
the inhibitor precipitates at concentrations above 0.003 mM | Bacillus anthracis | 4-[3-(9H-carbazol-9-yl)propoxy]-1-(4-methoxybenzyl)pyridin-2(1H)-one | |
0.003 | - |
larger than 0.003, inhibitor precipitates at concentrations larger 0.003 mM | Bacillus anthracis | 4-[3-(9H-carbazol-9-yl)propoxy]-1-(4-methoxybenzyl)pyridin-2(1H)-one | |
0.0036 | - |
- |
Bacillus anthracis | 4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzamide | |
0.0037 | - |
- |
Bacillus anthracis | 4-(benzyloxy)-1-(2-chloro-4-nitrobenzyl)pyridin-2(1H)-one | |
0.006 | - |
the inhibitor precipitates at concentrations above 0.006 mM | Bacillus anthracis | 4-[3-(9H-carbazol-9-yl)propoxy]-1-(2-chlorobenzyl)pyridin-2(1H)-one | |
0.006 | - |
larger than 0.006, inhibitor precipitates at concentrations larger 0.006 mM | Bacillus anthracis | 4-[3-(9H-carbazol-9-yl)propoxy]-1-(2-chlorobenzyl)pyridin-2(1H)-one | |
0.0068 | - |
- |
Bacillus anthracis | 1-benzyl-4-(benzyloxy)pyridin-2(1H)-one | |
0.007 | - |
- |
Bacillus anthracis | 4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzonitrile | |
0.0188 | - |
- |
Bacillus anthracis | 3-(2-chlorophenoxy)-6-methoxypyridin-2(1H)-one | |
0.0214 | - |
- |
Bacillus anthracis | 5-chloro-2-(2,4-dichlorophenoxy)pyridine 1-oxide | |
0.023 | - |
- |
Bacillus anthracis | 4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzoic acid | |
0.0237 | - |
- |
Bacillus anthracis | 3-(2,4-dichlorophenoxy)-6-methoxypyridin-2(1H)-one | |
0.0238 | - |
- |
Bacillus anthracis | 4-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]-3-chlorobenzoic acid | |
0.028 | - |
- |
Bacillus anthracis | 1-(2-chlorobenzyl)-4-[3-(1H-imidazol-1-yl)propoxy]pyridin-2(1H)-one | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | 5-(2-chlorophenoxy)-2-methoxypyridine 1-oxide | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | 4-hydroxy-1-(4-hydroxybenzyl)pyridin-2(1H)-one | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | 4-hydroxy-1-(4-methoxybenzyl)pyridin-2(1H)-one | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | 1-benzyl-4-[3-(9H-carbazol-9-yl)propoxy]pyridin-2(1H)-one | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | 1-benzyl-4-hydroxypyridin-2(1H)-one | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | [4-(benzyloxy)-2-oxopyridin-1(2H)-yl]acetonitrile | |
0.1 | - |
IC50 above 0.1 mM | Bacillus anthracis | ethyl 5-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]isoxazole-3-carboxylate | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | 5-(2-chlorophenoxy)-2-methoxypyridine 1-oxide | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | 4-hydroxy-1-(4-hydroxybenzyl)pyridin-2(1H)-one | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | 4-hydroxy-1-(4-methoxybenzyl)pyridin-2(1H)-one | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | 1-benzyl-4-[3-(9H-carbazol-9-yl)propoxy]pyridin-2(1H)-one | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | 1-benzyl-4-hydroxypyridin-2(1H)-one | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | [4-(benzyloxy)-2-oxopyridin-1(2H)-yl]acetonitrile | |
0.1 | - |
larger than 0.1, inhibition is less than 30% at 0.1 mM | Bacillus anthracis | ethyl 5-[[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl]isoxazole-3-carboxylate |