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Literature summary for 1.3.1.9 extracted from

  • Hirschbeck, M.W.; Kuper, J.; Lu, H.; Liu, N.; Neckles, C.; Shah, S.; Wagner, S.; Sotriffer, C.A.; Tonge, P.J.; Kisker, C.
    Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors (2012), Structure, 20, 89-100.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Yersinia pestis

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with NADH, and in complex with inhibitors 1-(2-chlorobenzyl)-4-hexylpyridin-2(1H)-one and 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one, to 0.92-1.54 A resolution. Without a substrate bound, it adopts a closed conformation that has to open to allow access of the enoyl substrate or an inhibitor Yersinia pestis

Inhibitors

Inhibitors Comment Organism Structure
1-(2-chlorobenzyl)-4-hexylpyridin-2(1H)-one competitive Yersinia pestis
1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one competitive Yersinia pestis
triclosan
-
 Yersinia pestis

Organism

Organism UniProt Comment Textmining
Yersinia pestis Q8Z9U1
-
-

Synonyms

Synonyms Comment Organism
FabV
-
 Yersinia pestis
YP_4011 locus name Yersinia pestis

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Yersinia pestis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 pH 6.8, 25°C Yersinia pestis 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one
0.0021
-
 pH 6.8, 25°C Yersinia pestis 1-(2-chlorobenzyl)-4-hexylpyridin-2(1H)-one
0.071
-
 pH 6.8, 25°C Yersinia pestis triclosan