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Literature summary for 1.3.1.9 extracted from

  • Ghattas, M.A.; Mansour, R.A.; Atatreh, N.; Bryce, R.A.
    Analysis of enoyl-acyl carrier protein reductase structure and interactions yields an efficient virtual screening approach and suggests a potential allosteric site (2016), Chem. Biol. Drug Des., 87, 131-142.
    View publication on PubMed
Search for more literature for 1.3.1.9

Inhibitors

Inhibitors Comment Organism Structure
triclosan
-
 Escherichia coli
triclosan
-
 Mycobacterium tuberculosis
triclosan
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an acyl-[acyl-carrier protein] + NAD+ Escherichia coli
-
 a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
an acyl-[acyl-carrier protein] + NAD+ Plasmodium falciparum
-
 a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
an acyl-[acyl-carrier protein] + NAD+ Mycobacterium tuberculosis
-
 a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
an acyl-[acyl-carrier protein] + NAD+ Mycobacterium tuberculosis H37Rv
-
 a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mycobacterium tuberculosis P9WGR1
-
-
Mycobacterium tuberculosis H37Rv P9WGR1
-
-
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an acyl-[acyl-carrier protein] + NAD+
-
 Escherichia coli a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
an acyl-[acyl-carrier protein] + NAD+
-
 Plasmodium falciparum a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
an acyl-[acyl-carrier protein] + NAD+
-
 Mycobacterium tuberculosis a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
an acyl-[acyl-carrier protein] + NAD+
-
 Mycobacterium tuberculosis H37Rv a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
 Escherichia coli
enoyl-ACP reductase
-
 Plasmodium falciparum
enoyl-ACP reductase
-
 Mycobacterium tuberculosis
enoyl-acyl carrier protein reductase
-
 Escherichia coli
enoyl-acyl carrier protein reductase
-
 Plasmodium falciparum
enoyl-acyl carrier protein reductase
-
 Mycobacterium tuberculosis
ENR
-
 Escherichia coli
ENR
-
 Plasmodium falciparum
ENR
-
 Mycobacterium tuberculosis
FabI
-
 Escherichia coli
FabI
-
 Plasmodium falciparum
InhA
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Escherichia coli
NADH
-
 Plasmodium falciparum
NADH
-
 Mycobacterium tuberculosis