Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli (BL21) | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide | - |
Mycobacterium tuberculosis | |
N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide | - |
Mycobacterium tuberculosis | |
N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide | - |
Mycobacterium tuberculosis | |
N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide | - |
Mycobacterium tuberculosis | |
N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(4-fluoro-2-(trifluoromethyl)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide | - |
Mycobacterium tuberculosis | |
N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide | - |
Mycobacterium tuberculosis | |
N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide | - |
Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WGR1 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WGR1 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-dodecenoyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis | dodecanoyl-CoA + NAD+ | - |
? | |
trans-2-dodecenoyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis ATCC 25618 | dodecanoyl-CoA + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
InhA | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | 2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide | |
0.00005 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide | |
0.00006 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide | |
0.00006 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide | |
0.00008 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide | |
0.00009 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide | |
0.00009 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.00009 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide | |
0.00012 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide | |
0.00025 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide | |
0.00025 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide | |
0.00032 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide | |
0.00035 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.0005 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.0005 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide | |
0.00054 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide | |
0.001 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide | |
0.00126 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.0014 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide | |
0.00158 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.00158 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.00158 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.00251 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.00251 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide | |
0.0031 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide | |
0.00325 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide | |
0.0034 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide | |
0.00593 | - |
pH 6.8, 25°C | Mycobacterium tuberculosis | N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide |