Literature summary for 1.3.1.9 extracted from

Mahfuz, A.; Stambuk Opazo, F.; Aguilar, L.; Iqbal, M.
Carfilzomib as a potential inhibitor of NADH-dependent enoyl-acyl carrier protein reductases of Klebsiella pneumoniae and Mycobacterium tuberculosis as a drug target enzyme insights from molecular docking and molecular dynamics (2020), J. Biomol. Struct. Dyn., 30, 1-17 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
carfilzomib	proteasome inhibitor, shows a high binding affinity and binds strongly to the active sites of FabI and FabV proteins, and Mycobacterium tuberculosis InhA; proteasome inhibitor, shows a high binding affinity and binds strongly to the active sites of FabI and FabV proteins, and Mycobacterium tuberculosis InhA	Klebsiella pneumoniae
carfilzomib	proteasome inhibitor, shows a high binding affinity and binds strongly to the active sites of Klebsiella pneumoniae FabI and FabV proteins, and Mycobacterium tuberculosis InhA	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	A0A0G3SXJ0	isoform FabV, cf. EC 1.3.1.44	-
Klebsiella pneumoniae	W9BFS8	isoform FabI	-
Mycobacterium tuberculosis	P9WGR1	-	-
Mycobacterium tuberculosis ATCC 25618	P9WGR1	-	-

Synonyms

Synonyms	Comment	Organism
FabV	-	Klebsiella pneumoniae
InhA	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)