Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2,4-dichlorophenyl)-3-(3-methylpyridin-2-yl)thiourea | 47% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(2-bromobenzyl)-3-(4-nitrophenyl)thiourea | 78% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(2-bromobenzyl)-3-phenylthiourea | 23% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(2-chlorobenzyl)-3-(4-nitrophenyl)thiourea | 72% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(2-chlorobenzyl)-3-phenylthiourea | 31% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(2-chlorobenzyl)-3-phenylurea | 14% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-methylpyridin-2-yl)thiourea | 22% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(3-methylpyridin-2-yl)-3-(2-(trifluoromethyl)phenyl)thiourea | 32% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(3-methylpyridin-2-yl)-3-(4-tolyl)thiourea | 23% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(3-methylpyridin-2-yl)-3-(naphthalen-2-yl)thiourea | 38% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(3-methylpyridin-2-yl)-3-phenylthiourea | 35% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(4-bromophenyl)-3-(3-methylpyridin-2-yl)thiourea | 25% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(4-fluorophenyl)-3-(3-methylpyridin-2-yl)thiourea | 17% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(4-iodophenyl)-3-(3-methylpyridin-2-yl)thiourea | 8% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
1-(4-methoxyphenyl)-3-(3-methylpyridin-2-yl)thiourea | 20% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
bedaquiline | - |
Mycobacterium tuberculosis | |
delamanid | - |
Mycobacterium tuberculosis | |
ethambutol | - |
Mycobacterium tuberculosis | |
isoniazid | - |
Mycobacterium tuberculosis | |
noxytiolin | - |
Mycobacterium tuberculosis | |
rifampicin | - |
Mycobacterium tuberculosis | |
thioacetazone | - |
Mycobacterium tuberculosis | |
thiocarlide | - |
Mycobacterium tuberculosis | |
thiopental | - |
Mycobacterium tuberculosis | |
triclosan | more than 99% inhibition at 0.05 mM | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WGR1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WGR1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
enoyl acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
InhA | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0156 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-(2-bromobenzyl)-3-phenylthiourea | |
0.0177 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-(2-chlorobenzyl)-3-(4-nitrophenyl)thiourea |