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Literature summary for 1.3.1.9 extracted from

  • Jayaraman, M.; Ramadas, K.
    An integrated computational investigation to unveil the structural impacts of mutation on the InhA structural gene of Mycobacterium tuberculosis (2020), J. Mol. Graph. Model., 101, 107768 .
    View publication on PubMed
Search for more literature for 1.3.1.9

Protein Variants

Protein Variants Comment Organism
V78A the isoniazid-resistant mutation increases the structural stability of the protein with higher NADH binding affinity Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
isoniazid
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-2-enoyl-[acyl-carrier protein] + NADH Mycobacterium tuberculosis
-
 acyl-[acyl-carrier protein] + NAD+
-
 ?
trans-2-enoyl-[acyl-carrier protein] + NADH Mycobacterium tuberculosis H37Rv
-
 acyl-[acyl-carrier protein] + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGR1
-
-
Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-2-enoyl-[acyl-carrier protein] + NADH
-
 Mycobacterium tuberculosis acyl-[acyl-carrier protein] + NAD+
-
 ?
trans-2-enoyl-[acyl-carrier protein] + NADH
-
 Mycobacterium tuberculosis H37Rv acyl-[acyl-carrier protein] + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-acyl carrier protein reductase
-
 Mycobacterium tuberculosis
InhA
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mycobacterium tuberculosis