Literature summary for 1.3.1.92 extracted from

Yuan, Y.; Liu, W.; Zhang, Q.; Xiang, L.; Liu, X.; Chen, M.; Lin, Z.; Wang, Q.; Liao, Z.
Overexpression of artemisinic aldehyde DELTA11(13) reductase gene - enhanced artemisinin and its relative metabolite biosynthesis in transgenic Artemisia annua L (2015), Biotechnol. Appl. Biochem., 62, 17-23 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene DBR2, overexpression in Artemisia annua under control of the CaMV 35S promoter via transfecton through Agrobacterium tumefaciens strain LBA4404 mediated leaf disc transformation, quantitative real-time PCR expression analysis, method evaluation	Artemisia annua

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
artemisinic aldehyde + NADPH + H+	Artemisia annua	-	(11R)-dihydroartemisinic aldehyde + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Artemisia annua	C5H429	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Artemisia annua	-
seedling	-	Artemisia annua	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
artemisinic aldehyde + NADPH + H+	-	Artemisia annua	(11R)-dihydroartemisinic aldehyde + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
artemisinic aldehyde DELTA11(13) reductase	-	Artemisia annua
Dbr2	-	Artemisia annua

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Artemisia annua

General Information

General Information	Comment	Organism
metabolism	artemisinic aldehyde 11 (13) reductase (DBR2) is the checkpoint enzyme catalyzing artemisinic aldehyde to form dihydroartemisinic aldehyde directly involved in artemisinin biosynthetic pathway	Artemisia annua

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Release 2023.1 (January 2023)