Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.93 extracted from

  • Kohlwein, S.D.; Eder, S.; Oh, C.S.; Martin, C.E.; Gable, K.; Bacikova, D.; Dunn, T.
    Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae (2001), Mol. Cell. Biol., 21, 109-125.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.93

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum highly enriched in a structure marking nuclear-vacuolar junctions Saccharomyces cerevisiae 5783
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q99190
-
-

Subunits

Subunits Comment Organism
More Tsc13p coimmunoprecipitates with Elo2p and Elo3p, which are required for veryl long chain fatty acid synthesis, suggesting that the elongating proteins are organized in a complex Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
enoyl reductase
-
 Saccharomyces cerevisiae
TSC13
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the tsc13 mutant accumulates high levels of long-chain bases as well as ceramides that harbor fatty acids with chain lengths shorter than 26 carbons. These phenotypes are exacerbated by the deletion of either the ELO2 or ELO3 gene, both of which are required for synthesis of very long chain fatty acids. Compromising the synthesis of malonyl coenzyme A by inactivating acetyl-CoA carboxylase in a tsc13 mutant is lethal Saccharomyces cerevisiae