Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4S)-1,2-bis(4-chlorophenyl)-5-[2-(2,4-difluorophenyl)-2-oxoethoxy]-4-methylpyrazolidin-3-one | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4,4-bis(6-phenylhexyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4,4-bis[2-(2,4-difluorophenyl)-2-oxoethyl]pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(2,4-dichlorobenzyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(2-ethylbutyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(2-phenylethyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(3-methoxybenzyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(3-oxo-3-phenylpropyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(3-phenylpropyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(4-oxo-4-phenylbutyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(4-phenylbutyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(5-phenylpentyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-(6-phenylhexyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-heptylpyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-[2-(2,4-difluorophenyl)-2-oxoethyl]-4-methylpyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-[2-(4-fluorophenyl)-2-oxoethyl]pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-[2-(diethylamino)ethyl]pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
1,2-bis(4-chlorophenyl)-4-[3-(trifluoromethyl)benzyl]pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4'-[[1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidin-4-yl]methyl]biphenyl-2-carbonitrile | - |
Mycobacterium tuberculosis | |
4,4-bis[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-(2-chlorobenzyl)-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-benzyl-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)-4-methylpyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-[2-(benzylsulfanyl)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-[2-[benzyl(ethyl)amino]ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis | |
4-[3,5-bis(trifluoromethyl)benzyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Mycobacterium tuberculosis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mycobacterium tuberculosis | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WJL9 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WJL9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetylenolpyruvylglucosamine + NADPH + H+ | - |
Mycobacterium tuberculosis | UDP-N-acetylmuramate + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH + H+ | - |
Mycobacterium tuberculosis H37Rv | UDP-N-acetylmuramate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EC 1.1.1.158 | formerly | Mycobacterium tuberculosis |
MurB | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mycobacterium tuberculosis | |
NADPH | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0052 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[2-(benzylsulfanyl)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.0054 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-[2-(4-fluorophenyl)-2-oxoethyl]pyrazolidine-3,5-dione | |
0.0056 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(4-phenylbutyl)pyrazolidine-3,5-dione | |
0.0058 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4,4-bis[2-(2,4-difluorophenyl)-2-oxoethyl]pyrazolidine-3,5-dione | |
0.0072 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4,4-bis(6-phenylhexyl)pyrazolidine-3,5-dione | |
0.0072 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4,4-bis[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.0089 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(6-phenylhexyl)pyrazolidine-3,5-dione | |
0.01 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(4-oxo-4-phenylbutyl)pyrazolidine-3,5-dione | |
0.01 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(5-phenylpentyl)pyrazolidine-3,5-dione | |
0.01 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(3-phenylpropyl)pyrazolidine-3,5-dione | |
0.011 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(2,4-dichlorobenzyl)pyrazolidine-3,5-dione | |
0.011 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4'-[[1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidin-4-yl]methyl]biphenyl-2-carbonitrile | |
0.011 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.012 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[3,5-bis(trifluoromethyl)benzyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.013 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(3-oxo-3-phenylpropyl)pyrazolidine-3,5-dione | |
0.018 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-[3-(trifluoromethyl)benzyl]pyrazolidine-3,5-dione | |
0.02 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)-4-methylpyrazolidine-3,5-dione | |
0.035 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(2-phenylethyl)pyrazolidine-3,5-dione | |
0.042 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-heptylpyrazolidine-3,5-dione | |
0.049 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-[2-(2,4-difluorophenyl)-2-oxoethyl]-4-methylpyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(2-phenylethyl)pyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (4S)-1,2-bis(4-chlorophenyl)-5-[2-(2,4-difluorophenyl)-2-oxoethoxy]-4-methylpyrazolidin-3-one | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(3-methoxybenzyl)pyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-(2-chlorobenzyl)-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-benzyl-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-(2-ethylbutyl)pyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[2-[benzyl(ethyl)amino]ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | |
0.05 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1,2-bis(4-chlorophenyl)-4-[2-(diethylamino)ethyl]pyrazolidine-3,5-dione |