BRENDA - Reference to 1.3.3.13; Id = 744181

the enzyme is encoded in the albonoursin biosynthetic gene cluster, albABC, genes albAB encode units for a cyclic dipeptide oxidase complex, responsible for generating two dehydrogenated double bonds

Nocardiopsis alba

additional information

generation of an albABC gene deletion mutant YL001 of Nocardiopsis alba, genetic organization, overview. Strain YL001 show no significant difference from the wild-type in colonial morphology, and it has a slightly vibrant growth on the MS agar, production of the cyclic dipeptides is abolished in the DELTAalbABC mutant

Nocardiopsis alba

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

Nocardiopsis alba

-

albonoursin + 2 H2O2

-

?

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

Nocardiopsis alba ATCC BAA-2165

-

albonoursin + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

Nocardiopsis alba

-

? + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

Nocardiopsis alba ATCC BAA-2165

-

? + 2 H2O2

-

?

Nocardiopsis alba

-

isolated from the guts of healthy honeybees in a year-round survey

-

Nocardiopsis alba ATCC BAA-2165

-

isolated from the guts of healthy honeybees in a year-round survey

-

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

-

744181

Nocardiopsis alba

albonoursin + 2 H2O2

-

?

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

-

744181

Nocardiopsis alba ATCC BAA-2165

albonoursin + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

-

744181

Nocardiopsis alba

? + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

-

744181

Nocardiopsis alba ATCC BAA-2165

? + 2 H2O2

-

?

additional information

albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2

744181

Nocardiopsis alba

?

-

additional information

albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2

744181

Nocardiopsis alba ATCC BAA-2165

?

-

the enzyme is encoded in the albonoursin biosynthetic gene cluster, albABC, genes albAB encode units for a cyclic dipeptide oxidase complex, responsible for generating two dehydrogenated double bonds

Nocardiopsis alba

additional information

generation of an albABC gene deletion mutant YL001 of Nocardiopsis alba, genetic organization, overview. Strain YL001 show no significant difference from the wild-type in colonial morphology, and it has a slightly vibrant growth on the MS agar, production of the cyclic dipeptides is abolished in the DELTAalbABC mutant

Nocardiopsis alba

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

Nocardiopsis alba

-

albonoursin + 2 H2O2

-

?

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

Nocardiopsis alba ATCC BAA-2165

-

albonoursin + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

Nocardiopsis alba

-

? + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

Nocardiopsis alba ATCC BAA-2165

-

? + 2 H2O2

-

?

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

-

744181

Nocardiopsis alba

albonoursin + 2 H2O2

-

?

cyclo(L-leucyl-L-phenylalanyl) + 2 O2

-

744181

Nocardiopsis alba ATCC BAA-2165

albonoursin + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

-

744181

Nocardiopsis alba

? + 2 H2O2

-

?

cyclo(L-methoxytyrosine-L-leucine) + 2 O2

-

744181

Nocardiopsis alba ATCC BAA-2165

? + 2 H2O2

-

?

additional information

albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2

744181

Nocardiopsis alba

?

-

additional information

albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2

744181

Nocardiopsis alba ATCC BAA-2165

?

-

malfunction

the albABC gene operon deletion mutant of Nocariopsis alba cannot produce cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu)

Nocardiopsis alba

metabolism

the albonoursin biosynthetic gene cluster is involved in the regulated biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

Nocardiopsis alba

physiological function

the enzyme is required for biosynthesis of antibacterial cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu)

Nocardiopsis alba

malfunction

the albABC gene operon deletion mutant of Nocariopsis alba cannot produce cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu)

Nocardiopsis alba

metabolism

the albonoursin biosynthetic gene cluster is involved in the regulated biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

Nocardiopsis alba

physiological function

the enzyme is required for biosynthesis of antibacterial cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu)

Nocardiopsis alba

744181

Li

Analysis of the biosynthesis ...

Nocardiopsis alba, Nocardiopsis alba ATCC BAA-2165

Arch. Microbiol.

196

765-774

2014

-

1

-

1

-

4

-

2

-

6

-

1

-

1

-

4

-

6

-

3

-

722021

Lautru

The albonoursin gene cluster o ...

Streptomyces noursei

Chem. Biol.

9

1355-1364

2002

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

722172

Gondry

Cyclic dipeptide oxidase from ...

Streptomyces noursei, Streptomyces noursei ATCC 11455

Eur. J. Biochem.

268

1712-1721

2001

-

1

2

-

2

4

-

3

-

1

-

2

16

1

-

2

1

-

1

-

1

-

2

-

2

4

-

1

-

2

16

1

-

2

1

-

Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

Data extracted from this reference: