Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.3.4 extracted from

  • Davids, L.M.; Corrigall, A.V.; Meissner, P.N.
    Mitochondrial targeting of human protoporphyrinogen oxidase (2006), Cell Biol. Int., 30, 416-426.
    View publication on PubMed
Search for more literature for 1.3.3.4

Application

Application Comment Organism
medicine variegate porphyria resulting from a deficiency in protoporphyrinogen oxidase Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant cDNAs cloned into the pEGFP-N1 vector and transiently transfected into HepG2 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H20A targets the mitochondrion Homo sapiens
H20E targets the mitochondrion Homo sapiens
H20G targets the mitochondrion Homo sapiens
H20K targets the mitochondrion Homo sapiens
H20P abolishes mitochondrial targeting, presumably through disruption of the protoporphyrinogen oxidase alpha-helix Homo sapiens
H20S targets the mitochondrion Homo sapiens
additional information constructs with reduction to 12 residues (PPOX12-GFP) and then subsequent increases to 14 (PPOX14-GFP), 15 (PPOX15-GFP) and 16 (PPOX16-GFP) residue constructs, lead to an abolition of mitochondrial targeting, however, a 17-residue construct (PPOX17-GFP) does effect mitochondrial targeting Homo sapiens
R168C targets the mitochondrion Homo sapiens
R59W targets the mitochondrion Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
PPOX
-
 Homo sapiens