Cloned (Comment) | Organism |
---|---|
gene hemG, DNA and amino acid sequence determination and analysis | Chlamydia trachomatis |
Protein Variants | Comment | Organism |
---|---|---|
G58S | naturally occuring mutation, suppresses the reduced infectivity caused by treatment with IS-INP0341, an iron-saturated salicylidene acylhydrazide SAH INP0341 | Chlamydia trachomatis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrinogen IX + 3 O2 | Chlamydia trachomatis | - |
protoporphyrin IX + 3 H2O2 | - |
? | |
protoporphyrinogen IX + 3 O2 | Chlamydia trachomatis 434/Bu | - |
protoporphyrin IX + 3 H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlamydia trachomatis | - |
propagated in HeLa cells, gene hemG | - |
Chlamydia trachomatis 434/Bu | - |
propagated in HeLa cells, gene hemG | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrinogen IX + 3 O2 | - |
Chlamydia trachomatis | protoporphyrin IX + 3 H2O2 | - |
? | |
protoporphyrinogen IX + 3 O2 | - |
Chlamydia trachomatis 434/Bu | protoporphyrin IX + 3 H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HemG | - |
Chlamydia trachomatis |
PPO | - |
Chlamydia trachomatis |
General Information | Comment | Organism |
---|---|---|
malfunction | mutation G58S in hemG suppresses the reduced infectivity caused by treatment with IS-INP0341, an iron-saturated salicylidene acylhydrazide SAH INP0341, which specifically affects Chlamydia trachomatis infectivity with reduced generation of infectious elementary body progeny | Chlamydia trachomatis |
metabolism | the enzyme catalyzes the aromatization of protoporphyrinogen IX to protoporphyrin IX, a central step in heme biosynthesis | Chlamydia trachomatis |
physiological function | protoporphyrinogen oxidase (HemG) and heme metabolism are important for Chlamydia trachomatis infectivity | Chlamydia trachomatis |