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Literature summary for 1.3.3.4 extracted from

  • Engstroem, P.; Nguyen, B.D.; Normark, J.; Nilsson, I.; Bastidas, R.J.; Gylfe, A.; Elofsson, M.; Fields, K.A.; Valdivia, R.H.; Wolf-Watz, H.; Bergstroem, S.
    Mutations in hemG mediate resistance to Salicylidene acylhydrazides: A novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity (2013), J. Bacteriol., 195, 4221-4230.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene hemG, DNA and amino acid sequence determination and analysis Chlamydia trachomatis

Protein Variants

Protein Variants Comment Organism
G58S naturally occuring mutation, suppresses the reduced infectivity caused by treatment with IS-INP0341, an iron-saturated salicylidene acylhydrazide SAH INP0341 Chlamydia trachomatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrinogen IX + 3 O2 Chlamydia trachomatis
-
protoporphyrin IX + 3 H2O2
-
?
protoporphyrinogen IX + 3 O2 Chlamydia trachomatis 434/Bu
-
protoporphyrin IX + 3 H2O2
-
?

Organism

Organism UniProt Comment Textmining
Chlamydia trachomatis
-
propagated in HeLa cells, gene hemG
-
Chlamydia trachomatis 434/Bu
-
propagated in HeLa cells, gene hemG
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoporphyrinogen IX + 3 O2
-
Chlamydia trachomatis protoporphyrin IX + 3 H2O2
-
?
protoporphyrinogen IX + 3 O2
-
Chlamydia trachomatis 434/Bu protoporphyrin IX + 3 H2O2
-
?

Synonyms

Synonyms Comment Organism
HemG
-
Chlamydia trachomatis
PPO
-
Chlamydia trachomatis

General Information

General Information Comment Organism
malfunction mutation G58S in hemG suppresses the reduced infectivity caused by treatment with IS-INP0341, an iron-saturated salicylidene acylhydrazide SAH INP0341, which specifically affects Chlamydia trachomatis infectivity with reduced generation of infectious elementary body progeny Chlamydia trachomatis
metabolism the enzyme catalyzes the aromatization of protoporphyrinogen IX to protoporphyrin IX, a central step in heme biosynthesis Chlamydia trachomatis
physiological function protoporphyrinogen oxidase (HemG) and heme metabolism are important for Chlamydia trachomatis infectivity Chlamydia trachomatis