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Literature summary for 1.3.3.6 extracted from

  • Vluggens, A.; Andreoletti, P.; Viswakarma, N.; Jia, Y.; Matsumoto, K.; Kulik, W.; Khan, M.; Huang, J.; Guo, D.; Yu, S.; Sarkar, J.; Singh, I.; Rao, M.S.; Wanders, R.J.; Reddy, J.K.; Cherkaoui-Malki, M.
    Reversal of mouse acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected] (2010), Lab. Invest., 90, 696-708.
    View publication on PubMed
Search for more literature for 1.3.3.6

Cloned(Commentary)

Cloned (Comment) Organism
expression of human ACOX1b isoform in a mouse ACOX1b mutant can reverse the null phenotype, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ACOX1-/- mice show twofold increased expression of isozyme ACOX1a compared to wild-type mice, ACOX1b-/- and ACOX1a-/- phenotypes, overview. Expression of human ACOX1b isoform in a mouse ACOX1b mutant can reverse the hepatic null phenotype, but with only weak reversal of the hepatic steatosis phenotype in the mice, overview. Expression of human isozyme ACOX1a has only poor effects Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Mus musculus 5777
-
peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + O2 Mus musculus
-
 trans-2,3-dehydropalmitoyl-CoA
-
 ?
palmitoyl-CoA + O2 Homo sapiens
-
 trans-2,3-dehydropalmitoyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 ACOX1a and ACOX1b isoforms are encoded by a single gene
-
Mus musculus
-
 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + O2
-
 Mus musculus trans-2,3-dehydropalmitoyl-CoA
-
 ?
palmitoyl-CoA + O2
-
 Homo sapiens trans-2,3-dehydropalmitoyl-CoA
-
 ?
palmitoyl-CoA + O2 isozyme ACOX1b shows higher activity than isozyme ACOX1a Homo sapiens trans-2,3-dehydropalmitoyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACOX1
-
 Mus musculus
ACOX1
-
 Homo sapiens
acyl-CoA oxidase 1
-
 Mus musculus
acyl-CoA oxidase 1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism ACOX1 is the first and rate-limiting enzyme of the peroxisomal beta-oxidation pathway Homo sapiens
physiological function ACOX1b controls the spontaneous hepatic peroxisome proliferation Homo sapiens