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Literature summary for 1.3.5.1 extracted from
- Kinetic characterization of succinate dehydrogenase (succinate: ubiquinone oxidoreductase) from Paracoccus denitrificans (1988), Biologia (Bratisl. ), 43, 1077-1085.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole | slightly activates | Paracoccus denitrificans |  |
| antimycin A | activates | Paracoccus denitrificans | |
| KCN | activation at 6.7 mM up to 10 mM when both alternative pathways to oxygen are inhibited | Paracoccus denitrificans | |
| malonate | activation | Paracoccus denitrificans | |
| Mucidin | activates | Paracoccus denitrificans | |
| succinate | activation | Paracoccus denitrificans | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-(n-Undecyl)-6-hydroxy-4,7-oxobenzothiazole | UHDBT | Paracoccus denitrificans | |
| CN- | not inhibitory: when mixed with succinate or alone | Paracoccus denitrificans | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.27 | - |
succinate | for both membrane fragments and mitochondrial enzyme | Paracoccus denitrificans | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Paracoccus denitrificans | 16020 | - |
| mitochondrion | - |
Paracoccus denitrificans | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paracoccus denitrificans | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.01 | - |
measured by the rate of dichloroindophenol reduction | Paracoccus denitrificans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ubiquinone | - |
Paracoccus denitrificans | fumarate + ubiquinol | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.2 | phosphate buffer | Paracoccus denitrificans |
| 7.3 | - |
Tris-acetate buffer | Paracoccus denitrificans |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7.5 | slow decline of activity at acidic pH, fast decline in alkaline range | Paracoccus denitrificans |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
enzyme activity falls abruptly | Paracoccus denitrificans |
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