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Literature summary for 1.3.5.1 extracted from
- Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase) (2003), Biochem. Biophys. Res. Commun., 311, 774-779.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloning of 2 distinct cDNAs of flavoprotein subunit of SQR | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| atpenin A5 | 0.0000042 mM, 50% inhibition | Homo sapiens |  |
| malonate | 0.18 mM, 50% inhibition | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ubiquinone | Homo sapiens | - |
fumarate + ubiquinol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | expression of 2 distinct flavoprotein subunits | Homo sapiens | - |
| heart | expression of 2 distinct flavoprotein subunits | Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| kidney | expression of 2 distinct flavoprotein subunits | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | expression of 2 distinct flavoprotein subunits | Homo sapiens | - |
| RAJI cell | express only type II Fp subunit of SQR complex | Homo sapiens | - |
| skeletal muscle | expression of 2 distinct flavoprotein subunits | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.024 | - |
SQR activity in raji cells | Homo sapiens |
| 0.039 | - |
SQR activity in HT-29 cells | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ubiquinone | - |
Homo sapiens | fumarate + ubiquinol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| complex II | - |
Homo sapiens |
| SQR | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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