Protein Variants | Comment | Organism |
---|---|---|
F69V | mutation in anchor subunit Sdh4, 56% of wild-type kcat | Saccharomyces cerevisiae |
H99L | mutation in anchor subunit Sdh4, 29% of wild-type kcat | Saccharomyces cerevisiae |
S71A | mutation in anchor subunit Sdh4, 43% of wild-type kcat | Saccharomyces cerevisiae |
Y89OCH | substitution with stop codon truncates Sdh4 by removing the third predicted transmembrane segment, 22% of wild-type activity | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-sec-butyl-4,6-dinitrophenol | non-competitive inhibition | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | 22°C | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Saccharomyces cerevisiae | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + ubiquinone | Saccharomyces cerevisiae | - |
fumarate + ubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | - |
Saccharomyces cerevisiae | fumarate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol | - |
? | |
succinate + ubiquinone | - |
Saccharomyces cerevisiae | fumarate + ubiquinol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
complex II | - |
Saccharomyces cerevisiae |
SDH | - |
Saccharomyces cerevisiae |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
no loss of activity after 10 min | Saccharomyces cerevisiae |
65 | - |
almost complete loss of activity after 10 min | Saccharomyces cerevisiae |
68 | - |
approx. 50% loss of activity after 10 min | Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.6 | - |
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | 22°C | Saccharomyces cerevisiae |