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Literature summary for 1.3.5.2 extracted from

  • Forman, H.J.; Kennedy, J.
    Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme (1978), Arch. Biochem. Biophys., 191, 23-31.
    View publication on PubMed
Search for more literature for 1.3.5.2

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Rattus norvegicus
additional information not: bathophenathroline, sulfonate, ethylendiaminetetraacetate, cyanide, azide Rattus norvegicus
Thenoyltrifluoroacetone
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0058
-
 2,6-dihydrophenolindophenol
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion inner membrane Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron iron-zinc protein Rattus norvegicus
Zinc iron-zinc protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydroorotate + acceptor Rattus norvegicus fourth step in pyrimidine biosynthesis orotate + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroorotate + acceptor acceptor: 2,6-dichlorophenolindophenol Rattus norvegicus orotate + reduced acceptor
-
 ?
dihydroorotate + acceptor acceptors: e.g. phenazine methosulfate Rattus norvegicus orotate + reduced acceptor
-
 ?
dihydroorotate + acceptor acceptor: ubiquinone Rattus norvegicus orotate + reduced acceptor
-
 ?
dihydroorotate + acceptor acceptor: oxygen, slowly Rattus norvegicus orotate + reduced acceptor
-
 ?
dihydroorotate + acceptor fourth step in pyrimidine biosynthesis Rattus norvegicus orotate + reduced acceptor
-
 ?
L-dihydroorotate + 2,6-dihydrophenolindophenol
-
 Rattus norvegicus orotate + reduced 2,6-dihydrophenolindophenol
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 dihydroorotate + 2,6-dichlorophenolindophenol Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FMN does not contain FMN Rattus norvegicus
additional information enzyme does not contain FAD, FMN, covalently bound flavin or ubiquinone Rattus norvegicus