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Literature summary for 1.3.7.11 extracted from

  • Murakami, M.; Shibuya, K.; Nakayama, T.; Nishino, T.; Yoshimura, T.; Hemmi, H.
    Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus (2007), FEBS J., 274, 805-814.
    View publication on PubMed
Search for more literature for 1.3.7.11

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli with a polyhistidine-tag at its N-terminus Archaeoglobus fulgidus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, SDS-PAGE Archaeoglobus fulgidus
46978
-
 x * 46978, calculated from sequence Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor Archaeoglobus fulgidus the enzyme is involved in the biosynthesis of archaeal membrane lipids 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus O29786
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Archaeoglobus fulgidus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme is involved in the biosynthesis of archaeal membrane lipids Archaeoglobus fulgidus 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
-
 ?
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro Archaeoglobus fulgidus 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
-
 ?
3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro Archaeoglobus fulgidus ?
-
 ?
geranylgeranyl diphosphate + reduced acceptor the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro Archaeoglobus fulgidus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, SDS-PAGE Archaeoglobus fulgidus
? x * 46978, calculated from sequence Archaeoglobus fulgidus

Synonyms

Synonyms Comment Organism
AF0464
-
 Archaeoglobus fulgidus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
 assay at Archaeoglobus fulgidus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Archaeoglobus fulgidus

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme, contains noncovalently bound FAD Archaeoglobus fulgidus
additional information the enzyme requires sodium dithionite as the electron donor for activity in vitro. In the presence of NADPH (the preferred electron donor for plant homologues), the enzyme reaction does not proceed Archaeoglobus fulgidus