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Literature summary for 1.3.7.11 extracted from
- Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product (2008), J. Bacteriol., 190, 3923-3929.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Sulfolobus acidocaldarius |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor | Sulfolobus acidocaldarius | the enzyme is involved in the biosynthesis of archaeal membrane lipids | 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sulfolobus acidocaldarius | Q4JA33 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sulfolobus acidocaldarius |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor | the enzyme is involved in the biosynthesis of archaeal membrane lipids | Sulfolobus acidocaldarius | 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor | - |
? | |
| 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor | most preferred substrate. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor | Sulfolobus acidocaldarius | 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor | - |
? | |
| 3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor | activity is comparable to the activity with 2,3-di-O-geranylgeranyl-sn-glycerol 1-phosphate as substrate | Sulfolobus acidocaldarius | 3-O-phytyl-sn-glycerol 1-phosphate + acceptor | - |
? | |
| geranylgeranyl diphosphate + reduced acceptor | the enzyme does not accept NADPH. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity compared to the complete reduction of 2,3-di-O-phytanyl-sn-glycerol 1-phosphate | Sulfolobus acidocaldarius | phytyl diphosphate + acceptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| geranylgeranyl reductase | - |
Sulfolobus acidocaldarius |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | the enzyme contains a flavin coenzyme | Sulfolobus acidocaldarius | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in the biosynthesis of archaeal membrane lipids | Sulfolobus acidocaldarius |
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