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Literature summary for 1.3.7.5 extracted from

  • Alvey, R.M.; Biswas, A.; Schluchter, W.M.; Bryant, D.A.
    Effects of modified phycobilin biosynthesis in the cyanobacterium Synechococcus sp. strain PCC 7002 (2011), J. Bacteriol., 193, 1663-1671.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.7.5

Protein Variants

Protein Variants Comment Organism
additional information insertional inactivation of pcyA is not possible in wild-type Synechococcus sp. strain PCC 7002 due to lethality of the mutant, but in a variant heterologously expressing HY2 from Arabidopsis thaliana encoding a phytochromobilin:ferredoxin oxidoreductase Synechococcus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biliverdin Ixalpha + reduced ferredoxin Synechococcus sp.
-
 (3Z)-phycocyanobilin + oxidized ferredoxin
-
 ?
biliverdin Ixalpha + reduced ferredoxin Synechococcus sp. PCC 7335
-
 (3Z)-phycocyanobilin + oxidized ferredoxin
-
 ?

Organism

Organism UniProt Comment Textmining
Synechococcus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin Ixalpha + reduced ferredoxin
-
 Synechococcus sp. (3Z)-phycocyanobilin + oxidized ferredoxin
-
 ?
biliverdin Ixalpha + reduced ferredoxin phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha Synechococcus sp. (3Z)-phycocyanobilin + oxidized ferredoxin
-
 ?
biliverdin Ixalpha + reduced ferredoxin
-
 Synechococcus sp. PCC 7335 (3Z)-phycocyanobilin + oxidized ferredoxin
-
 ?
biliverdin Ixalpha + reduced ferredoxin phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha Synechococcus sp. PCC 7335 (3Z)-phycocyanobilin + oxidized ferredoxin
-
 ?

Synonyms

Synonyms Comment Organism
PCB:ferredoxin oxidoreductase
-
 Synechococcus sp.
PcyA
-
 Synechococcus sp.
phycocyanobilin synthase
-
 Synechococcus sp.

Cofactor

Cofactor Comment Organism Structure
Ferredoxin
-
 Synechococcus sp.

General Information

General Information Comment Organism
evolution synthesis of linear tetrapyrrole chromophores in cyanobacteria, algae, and plants, ooverview Synechococcus sp.
malfunction because PcyA and PebA, EC 1.3.7.6/1.3.7.3, utilize the same substrate, biliverdin IXalpha, severe overexpression of pebA can limit the availability of phycocyanobilin, which appears to be required for viability when cells are grown in continuous light Synechococcus sp.
physiological function the pcyA gene of Synechococcus sp. strain PCC 7002 is essential Synechococcus sp.