Literature summary for 1.3.8.1 extracted from

Stagi, S.; Gasperini, S.; Manoni, C.; Greco, A.; Funghini, S.; Donati, A.
Autoimmune Thyroiditis, Pernicious Anaemia, Vitiligo and Scleroatrophic Lichen in a boy with short-chain acylCoA dehydrogenase deficiency (2010), Horm. Res. Paediatr., 73, 409-413.

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Cloned(Commentary)

Cloned (Comment)	Organism
SCAD DNA and amino acid sequence determination and analysis, the enzyme is encoded at 12q22-qter	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	subunits of the SCAD enzyme are synthesised in the cytosol as precursor proteins that are then imported into the mitochondrial matrix	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	subunits of the SCAD enzyme are synthesised in the cytosol as precursor proteins that are then imported into the mitochondrial matrix	Homo sapiens

Synonyms

Synonyms	Comment	Organism
SCAD	-	Homo sapiens
short-chain acylCoA dehydrogenase	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	SCAD functions in mitochondria and is involved in the beta-oxidation of fatty acyl-CoA compounds in chains of 4-6 carbons.The mitochondrial pathway of fatty acid beta-oxidation is an alternative source of energy, especially during stress or fasting	Homo sapiens
additional information	patients with short-chain acyl-CoA dehydrogenase deficiency, a rare disorder of fatty acid oxidation, may show an increased risk of thyroid and other autoimmune diseases. The pathologic phenotype can include pernicious anaemia, vitiligo, autoimmune thyroiditis and lichen scleroatrophicus, overview	Homo sapiens

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Release 2023.1 (January 2023)