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Literature summary for 1.3.8.4 extracted from
- Deuterium incorporation experiments from (3R)- and (3S)-[3-2H]leucine into characteristic isoprenoidal lipid-core of halophilic archaea suggests the involvement of isovaleryl-CoA dehydrogenase (2017), Biosci. Biotechnol. Biochem., 81, 2062-2070 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isovaleryl-CoA + electron-transfer flavoprotein | Halobacterium salinarum | - |
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Halobacterium salinarum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isovaleryl-CoA + electron-transfer flavoprotein | - |
Halobacterium salinarum | 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein | - |
? | |
| isovaleryl-CoA + electron-transfer flavoprotein | reaction via an alpha,beta-dehydrogenation step | Halobacterium salinarum | 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| electron transferring flavoprotein | ETF | Halobacterium salinarum | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | isovaleryl-CoA dehydrogenase (and its corresponding gene) is widely distributed in mammals, plants, and bacteria. This enzyme belongs to the acyl-CoA dehydrogenase family, which are responsible for hydrogen transfer in flavoproteins | Halobacterium salinarum |
| metabolism | involvement of isovaleryl-CoA dehydrogenase in leucine conversion to isoprenoid lipid in halophilic archaea, involvement of the leucine-to-mevalonate pathway, especially isovaleryl-CoA dehydrogenase, in the production of 3-methylcrotonyl-CoA. Branched amino acids are metabolized to mevalonate in archaea in a manner similar to other organisms, metabolic pathway overview | Halobacterium salinarum |
| additional information | the enzyme reactions stereochemical course is anti-elimination | Halobacterium salinarum |
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Release 2023.1 (January 2023)
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