Literature summary for 1.3.8.8 extracted from

McAndrew, R.P.; Wang, Y.; Mohsen, A.W.; He, M.; Vockley, J.; Kim, J.J.
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase (2008), J. Biol. Chem., 283, 9435-9443.

Search for more literature for 1.3.8.8

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli C43 (DE3) cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
complexed with myristoyl-CoA, hanging drop vapour diffusion method, in 0.1 M HEPES, pH 7.5, 17.6% polyethylene glycol 2000, 0.047 M MgCl2, and 5% glycerol	Homo sapiens
in complex with myristoyl-CoA, sitting drop vapour diffusion method, in 0.1 M HEPES, pH 7.5, 17.6% polyethylene glycol 2000, 0.047 M MgCl2, and 5% glycerol	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial membrane	-	Homo sapiens	31966	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
ammonium sulfate precipitation and DEAE-Sepharose Fast Flow column chromatography	Homo sapiens
DEAE-Sepharose Fast Flow column chromatography and SP-Sepharose Fast Flow column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
myristoyl-CoA + acceptor	-	Homo sapiens	2-tetradecenoyl-CoA + reduced acceptor	-	?
myristoyl-CoA + acceptor	-	Homo sapiens	trans(2)-tetradecenoyl-CoA + reduced acceptor	-	?

Subunits

Subunits	Comment	Organism
homodimer	x-ray crystallography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
very-long-chain acyl-CoA dehydrogenase	-	Homo sapiens
very-long-chain acyl-CoA dehydrogenase	most active with C14 substrates	Homo sapiens
VLCAD	-	Homo sapiens
VLCAD	optimal chain length specificity for fatty acyl-CoAs having 16 carbons in length	Homo sapiens

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Release 2023.1 (January 2023)