Application | Comment | Organism |
---|---|---|
medicine | LCAD gene replacement to the tibialis anterior muscle and livers of partially deficient LCAD mice is described, a surrogate model for human VLCAD deficiency | Mus musculus |
Cloned (Comment) | Organism |
---|---|
a vector plasmid pCB-mLCAD for transfection of LCAD-deficient mice is used | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
44000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mice heterozygous for a mutation in LCAD, strain B6.129S6-Acadltm1Uab Hsd | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
tibialis anterior | muscle | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.06037 | - |
LCAD enzyme activity in livers of partially deficient LCAD mice 8 weeks after injection of recombinant adeno-associated viral mLCAD vector via the hepatic portal vein | Mus musculus |
0.2546 | - |
LCAD enzyme activity in tibialis anterior muscle of LCAD-heterozygous deficient mice 10 weeks post-injection 1 x 10exp11 vg recombinant adeno-associated viral mLCAD | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methylheptanoyl-CoA + acceptor | activity assay | Mus musculus | ? | - |
? | |
palmitoyl-CoA + acceptor | activity assay | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAD | - |
Mus musculus |
long chain acyl coenzyme A dehydrogenase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
32 | - |
activity assay | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
activity assay | Mus musculus |