Literature summary for 1.3.98.4 extracted from

Miller, P.; Sjolander, N.; Nalesnyk, S.; Arnold, N.; Johnson, S.; Doerschuk, A.; McCormick, J.
Cosynthetic factor I, a factor involved in hydrogen-transfer in Streptomyces aureofaciens [4] (1960), J. Am. Chem. Soc., 82, 5002-5003.

No PubMed abstract available

Search for more literature for 1.3.98.4

Organism

Organism	UniProt	Comment	Textmining
Kitasatospora aureofaciens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-chloro-5a,11a-dehydrotetracycline + reduced cosynthetic factor-1	-	Kitasatospora aureofaciens	7-chlorotetracycline + oxidized cosynthetic factor-1	-	?
tetracycline + oxidized coenzyme F420	-	Kitasatospora aureofaciens	5a,11a-dehydrotetracycline + reduced coenzyme F420	-	?

Cofactor

Cofactor	Comment	Organism	Structure
additional information	cosynthetic factor-1 enables Streptomyces aureofaciens to produce tetracycline instead of their 5a,11a-dehydro analogues	Kitasatospora aureofaciens
additional information	isolation of Cosynthetic Factor I, required for catayltic activity. The factor is dialysable and stable to autoclaving over the pH range of 1 to 10	Kitasatospora aureofaciens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)