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Literature summary for extracted from

  • Miller, P.; Sjolander, N.; Nalesnyk, S.; Arnold, N.; Johnson, S.; Doerschuk, A.; McCormick, J.
    Cosynthetic factor I, a factor involved in hydrogen-transfer in Streptomyces aureofaciens [4] (1960), J. Am. Chem. Soc., 82, 5002-5003.
No PubMed abstract available


Organism UniProt Comment Textmining
Kitasatospora aureofaciens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-chloro-5a,11a-dehydrotetracycline + reduced cosynthetic factor-1
Kitasatospora aureofaciens 7-chlorotetracycline + oxidized cosynthetic factor-1
tetracycline + oxidized coenzyme F420
Kitasatospora aureofaciens 5a,11a-dehydrotetracycline + reduced coenzyme F420


Cofactor Comment Organism Structure
additional information cosynthetic factor-1 enables Streptomyces aureofaciens to produce tetracycline instead of their 5a,11a-dehydro analogues Kitasatospora aureofaciens
additional information isolation of Cosynthetic Factor I, required for catayltic activity. The factor is dialysable and stable to autoclaving over the pH range of 1 to 10 Kitasatospora aureofaciens