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Literature summary for extracted from

  • Dailey, H.; Gerdes, S.; Dailey, T.; Burch, J.; Phillips, J.
    Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin (2015), Proc. Natl. Acad. Sci. USA, 112, 2210-2215 .
    View publication on PubMedView publication on EuropePMC


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General Information

General Information Comment Organism
physiological function Actinobacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protoporphyrin. Instead, they oxidize coproporphyrinogen to coproporphyrin, insert ferrous iron to make Fe-coproporphyrin (coproheme), and then decarboxylate coproheme to generate protoheme. This pathway is specified by three genes named hemY, hemH, and hemQ and is the most ancient heme synthesis pathway in the Eubacteria Firmicutes