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Literature summary for 1.3.99.38 extracted from

  • Upadhyay, A.; Fontes, F.L.; Gonzalez-Juarrero, M.; McNeil, M.R.; Crans, D.C.; Jackson, M.; Crick, D.C.
    Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase, MenJ (2015), ACS Cent. Sci., 1, 292-302.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.99.38

Application

Application Comment Organism
pharmacology menaquinone synthesis may be a drug target in Mycobacteria Mycolicibacterium smegmatis
pharmacology menaquinone synthesis may be a drug target in Mycobacterium tuberculosis Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 Mycobacterium tuberculosis
expressed in Escherichia coli BL21 Mycolicibacterium smegmatis

Protein Variants

Protein Variants Comment Organism
J774A the mutant is capable of infecting host cell but incapable of surviving in the macrophage Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WNY9
-
-
Mycobacterium tuberculosis H37Rv P9WNY9
-
-
Mycolicibacterium smegmatis A0QRI8
-
-
Mycolicibacterium smegmatis ATCC 700084 A0QRI8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menaquinone-9 + reduced acceptor
-
 Mycobacterium tuberculosis beta-dihydromenaquinone-9 + acceptor beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated ?
menaquinone-9 + reduced acceptor
-
 Mycolicibacterium smegmatis beta-dihydromenaquinone-9 + acceptor beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated ?
menaquinone-9 + reduced acceptor
-
 Mycolicibacterium smegmatis ATCC 700084 beta-dihydromenaquinone-9 + acceptor beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated ?
menaquinone-9 + reduced acceptor
-
 Mycobacterium tuberculosis H37Rv beta-dihydromenaquinone-9 + acceptor beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated ?

Synonyms

Synonyms Comment Organism
MenJ
-
 Mycobacterium tuberculosis
MenJ
-
 Mycolicibacterium smegmatis
MSMEG1132 locus name Mycolicibacterium smegmatis
Rv0561c locus name Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Mycobacterium tuberculosis
FAD
-
 Mycolicibacterium smegmatis