Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
identificaion of putative inhibitors by molecular docking | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(isonicotinamido)-N2,N4-bis(benzo[d]thiazol-2-yl)azetidine-2,4-dicarboxamide | compound shows 100fold reduction in nutrient starved dormant Mycobacterium tuberculosis model and MIC of 11.81 microM in actively replicative Mycobacterium tuberculosis | Mycobacterium tuberculosis | |
1-(isonicotinamido)-N2,N4-bis(phenyl)azetidine-2,4-dicarboxamide | lead compound for inhibitor screening, involved in hydrophobic interactions with residues Pro242, Val241, Ala176, Leu130, Ile267, Ala179, Ile199 and Ile174 | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WQB1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WQB1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Rv2780 | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0038 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 1-(isonicotinamido)-N2,N4-bis(benzo[d]thiazol-2-yl)azetidine-2,4-dicarboxamide | |
0.0092 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 1-(isonicotinamido)-N2,N4-bis(phenyl)azetidine-2,4-dicarboxamide |