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Literature summary for 1.4.1.10 extracted from
- Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions (1982), Infect. Immun., 37, 1042-1049.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| oxygen | - |
Mycobacterium tuberculosis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0087 | - |
NADH | anaerobic resting bacilli - RB | Mycobacterium tuberculosis | |
| 4.3 | - |
glyoxylate | aerobic aerated bacilli - AB | Mycobacterium tuberculosis | |
| 5.4 | - |
glyoxylate | anaerobic resting bacilli - RB | Mycobacterium tuberculosis | |
| 120 | - |
NH3 | anaerobic resting bacilli - RB | Mycobacterium tuberculosis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
in vitro under anerobic conditions approximately 10fold greater than under aerobic conditions | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glyoxylate + NH3 + NADH | - |
Mycobacterium tuberculosis | glycine + H2O + NAD+ | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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