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Literature summary for 1.4.1.11 extracted from
- Aerobic metabolism of 3,5-diaminohexanoate in a Brevibacterium. Purification of 3,5-diaminohexanoate dehydrogenase and degradation of 3-keto-5-aminohexanoate (1973), J. Biol. Chem., 248, 41-49.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-erythro-3,5-diaminohexanoate | - |
Brevibacterium L5 |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.75 | - |
L-erythro-3,5-diaminohexanoate | pH 9.3 | Brevibacterium L5 | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 71000 | - |
gel filtration | Brevibacterium L5 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-erythro-3,5-diaminohexanoate + H2O + NAD+ | Brevibacterium L5 | 3-keto-5-aminohexanoate has the (5S) configuration. First step in the decomposition of 3,5-diaminohexanoate by the aerobic Brevibacterium L5 | 5-amino-3-oxohexanoate + NH3 + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brevibacterium L5 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Brevibacterium L5 |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 4 months, enzyme in cells extract is stable for 4 months | Brevibacterium L5 |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-erythro-3,5-diaminohexanoate + H2O + NAD+ | 3-keto-5-aminohexanoate has the (5S) configuration. First step in the decomposition of 3,5-diaminohexanoate by the aerobic Brevibacterium L5 | Brevibacterium L5 | 5-amino-3-oxohexanoate + NH3 + NADH + H+ | - |
r | |
| L-erythro-3,5-diaminohexanoate + H2O + NAD+ | 3-keto-5-aminohexanoate has the (5S) configuration | Brevibacterium L5 | 5-amino-3-oxohexanoate + NH3 + NADH + H+ | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.3 | - |
- |
Brevibacterium L5 |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | 10.2 | pH 8.3: about 55% of maximal activity, pH 10.2: about 60% of maximal activity | Brevibacterium L5 |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8.5 | enzyme is most stable between pH 7.0 and 8.5 | Brevibacterium L5 |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Brevibacterium L5 | |
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