Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyglutarate | D- and L-isomer, most potent competitive inhibitor | Lupinus angustifolius | |
2-oxoglutarate | - |
Lupinus angustifolius | |
aspartate | weak inhibition, competitive with 2-oxoglutarate | Lupinus angustifolius | |
D-2-hydroxyglutarate | - |
Lupinus angustifolius | |
D-glutamate | competitive inhibitor | Lupinus angustifolius | |
Glutarate | most potent competitive inhibitor | Lupinus angustifolius | |
L-2-hydroxyglutarate | - |
Lupinus angustifolius | |
L-glutamate | competitive with 2-oxoglutarate | Lupinus angustifolius | |
oxaloacetate | weak inhibition, competitive with 2-oxoglutarate | Lupinus angustifolius |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.024 | - |
2-oxoglutarate | - |
Lupinus angustifolius |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + 2-oxoglutarate + NADH | Lupinus angustifolius | ammonia assimilation from fixed nitrogen, de novo synthesis of glutamate | glutamate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lupinus angustifolius | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root nodule | - |
Lupinus angustifolius | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + 2-oxoglutarate + NADH | absolute specificity for 2-oxoglutarate | Lupinus angustifolius | L-glutamate + NAD+ | - |
? | |
L-glutamine + 2-oxoglutarate + NADH | ammonia assimilation from fixed nitrogen, de novo synthesis of glutamate | Lupinus angustifolius | glutamate + NAD+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Lupinus angustifolius |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
L-2-hydroxyglutarate | - |
Lupinus angustifolius | |
0.28 | - |
D-2-hydroxyglutarate | - |
Lupinus angustifolius | |
0.35 | - |
Glutarate | - |
Lupinus angustifolius | |
0.6 | - |
L-glutamate | - |
Lupinus angustifolius | |
0.6 | - |
D-glutamate | - |
Lupinus angustifolius | |
2.7 | - |
L-aspartate | - |
Lupinus angustifolius | |
5 | - |
oxaloacetate | - |
Lupinus angustifolius |