Literature summary for 1.4.1.16 extracted from

Bartlett, A.T.M.; White, P.J.
Species of Bacillus that make a vegetative peptidoglycan containing lysine lack diaminopimelate epimerase but have diaminopimelate dehydrogenase (1985), J. Gen. Microbiol., 131, 2145-2152.

No PubMed abstract available

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	Lysinibacillus sphaericus	-	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	Paenibacillus macerans	-	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	Sporosarcina pasteurii	-	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	Sporosarcina globispora	-	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Lysinibacillus sphaericus	-	-	-
Paenibacillus macerans	-	-	-
Sporosarcina globispora	-	-	-
Sporosarcina pasteurii	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.12	-	activity in crude extracts	Paenibacillus macerans
0.19	-	activity in crude extracts	Sporosarcina globispora
0.53	-	activity in crude extracts	Sporosarcina pasteurii

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	-	Lysinibacillus sphaericus	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	-	Paenibacillus macerans	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	-	Sporosarcina pasteurii	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	-	Sporosarcina globispora	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	-	Lysinibacillus sphaericus	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	-	Paenibacillus macerans	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	-	Sporosarcina pasteurii	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	-	Sporosarcina globispora	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Lysinibacillus sphaericus
NADPH	-	Paenibacillus macerans
NADPH	-	Sporosarcina pasteurii
NADPH	-	Sporosarcina globispora

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Release 2023.1 (January 2023)