Literature summary for 1.4.1.16 extracted from

Zhao, L.; Liu, W.; Chen, X.; Wang, M.; Feng, J.; Wu, Q.; Zhu, D.
Effect of residue Y76 on co-enzyme specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum (2015), Chin. J. Biotechnol., 31, 1108-1118 .

Search for more literature for 1.4.1.16

Protein Variants

Protein Variants	Comment	Organism
R35S/R36V	the mutations significantly lower the specific activity toward NADP+ compared to the wild type enzyme. The mutant enzyme favors NAD+ over NADP+	Symbiobacterium thermophilum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
meso-2,6-diaminoheptanedioate + H2O + NADP+	Symbiobacterium thermophilum	-	L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Symbiobacterium thermophilum	Q67PI3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
meso-2,6-diaminoheptanedioate + H2O + NADP+	-	Symbiobacterium thermophilum	L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
DAPDH	-	Symbiobacterium thermophilum
meso-diaminopimelate dehydrogenase	-	Symbiobacterium thermophilum

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Symbiobacterium thermophilum

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Release 2023.1 (January 2023)