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Literature summary for 1.4.1.27 extracted from

  • Yoshida, T.; Kikuchi, G.
    Significance of the glycine cleavage system in glycine and serine catabolism in avian liver (1971), Arch. Biochem. Biophys., 145, 658-668 .
    View publication on PubMed
Search for more literature for 1.4.1.27

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Columba sp. 5739
-
mitochondrion
-
 Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + tetrahydrofolate + NAD+ Columba sp.
-
 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?
glycine + tetrahydrofolate + NAD+ Gallus gallus
-
 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Columba sp.
-
-
-
Gallus gallus P15505 i.e. component P-protein, glycine dehydrogenase, cf. EC 1.4.4.2
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Columba sp.
-
liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + tetrahydrofolate + NAD+
-
 Columba sp. 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?
glycine + tetrahydrofolate + NAD+
-
 Gallus gallus 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?

General Information

General Information Comment Organism
metabolism liver mitochondria actively catalyze the cleavage of glycine into methylene-THF, CO2, and ammonia, but fail to appreciably catalyze CO2 formation from the alpha-carbon of glycine. The one-carbon compound derived from glycine in the avian livers is utilized largely for the synthesis of uric acid. The yields of 14C-hypoxanthine from 14C-glycine, especially from glycine-2-14C, are significantly increased by the addition of mitochondria to the soluble liver fraction, and under these conditions the ratio of the yields of 14C-hypoxanthine from glycine-l-14C and 2-14C rises to 1:2.3 Columba sp.
metabolism liver mitochondria actively catalyze the cleavage of glycine into methylene-THF, CO2, and ammonia, but fail to appreciably catalyze CO2 formation from the alpha-carbon of glycine. The one-carbon compound derived from glycine in the avian livers is utilized largely for the synthesis of uric acid. The yields of 14C-hypoxanthine from 14C-glycine, especially from glycine-2-14C, are significantly increased by the addition of mitochondria to the soluble liver fraction, and under these conditions the ratio of the yields of 14C-hypoxanthine from glycine-l-14C and 2-14C rises to 1:2.3 Gallus gallus