Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxo-3-methylvalerate | competitive with respect to glycine, presence leads to a decrease of apparent Km for NAD with a concomitant decrease of Vmax | Rattus norvegicus | |
2-oxoglutarate | competitive with respect to glycine, presence leads to a decrease of apparent Km for NAD with a concomitant decrease of Vmax | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | the lipoamide dehydrogenase component, cf. EC 1.8.1.4, is an indistinguishable constituent among alpha-keto acid dehydrogenase complexes and the glycine cleavage system in mitochondria in nature, and lipoamide dehydrogenase-mediated transfer of reducing equivalents might regulate alpha-keto acid oxidation as well as glycine oxidation | Rattus norvegicus |