Literature summary for 1.4.1.27 extracted from

Vazquez, A.; Markert, E.K.; Oltvai, Z.N.
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation (2011), PLoS ONE, 6, e25881 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	construction of a genome-scale model of human cell metabolism to investigate the potential metabolic alterations in cells using net zero ATP glycolysis. A pathway for ATP generation involves reactions from serine biosynthesis, one-carbon metabolism and the glycine cleavage system, and is transcriptionally upregulated in an inducible murine model of Myc-driven liver tumorigenesis. This pathway has a predicted two-fold higher flux rate in cells using net zero ATP glycolysis than those using standard glycolysis and generates twice as much ATP with significantly lower rate of lactate, but higher rate of alanine secretion	Homo sapiens

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Release 2023.1 (January 2023)