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Literature summary for 1.4.1.3 extracted from
- Glutamate dehydrogenase (1975), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 11, 293-367.
No PubMed abstract available
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Gallus gallus |
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Sus scrofa |
- |
Bos taurus |
- |
Auxenochlorella pyrenoidosa |
- |
Squalus acanthias |
- |
Acholeplasma laidlawii |
- |
Thunnus thynnus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | - |
Bos taurus |  |
| 5-Bromofuroate | - |
Bos taurus | |
| 5-Chlorofuroate | - |
Bos taurus | |
| 5-Nitrofuroate | - |
Bos taurus | |
| alpha-Ketoglutarate oxime | - |
Bos taurus | |
| alpha-Monofluoroglutarate | - |
Bos taurus | |
| alpha-Tetrazole | - |
Bos taurus | |
| Ditetrazole | - |
Bos taurus | |
| fumarate | - |
Bos taurus | |
| gamma-Tetrazole | - |
Bos taurus | |
| glutamate | - |
Bos taurus | |
| Glutarate | - |
Bos taurus | |
| Glyoxal | - |
Bos taurus | |
| imidodiacetic acid | - |
Bos taurus | |
| isophthalate | - |
Bos taurus | |
| isophthalate | - |
Thunnus thynnus | |
| m-bromobenzoate | - |
Bos taurus | |
| m-chlorobenzoate | - |
Bos taurus | |
| m-iodobenzoate | - |
Bos taurus | |
| m-Nitrobenzoate | - |
Bos taurus | |
| Oxydiglycolic acid | - |
Bos taurus | |
| Thiodiglycolic acid | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Gallus gallus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Sus scrofa | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| mitochondrion | - |
Lithobates catesbeianus | 5739 | - |
| mitochondrion | - |
Squalus acanthias | 5739 | - |
| mitochondrion | - |
Thunnus thynnus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 240000 | 260000 | sucrose density gradient sedimentation | Acholeplasma laidlawii |
| 250000 | - |
liver enzyme, sedimentation velocity, light scattering | Sus scrofa |
| 300000 | 350000 | liver, light scattering | Sus scrofa |
| 300000 | 350000 | liver, sedimentation velocity | Gallus gallus |
| 300000 | 350000 | liver, sedimentation equilibrium | Rattus norvegicus |
| 300000 | 350000 | liver, sedimentation equilibrium | Thunnus thynnus |
| 300000 | 350000 | liver, light scattering, sedimentation equilibrium | Bos taurus |
| 333000 | - |
sedimentation equilibrium | Thunnus thynnus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acholeplasma laidlawii | - |
- |
- |
| Auxenochlorella pyrenoidosa | - |
- |
- |
| Bos taurus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Lithobates catesbeianus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Squalus acanthias | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Thunnus thynnus | - |
tuna | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ | mechanism | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Gallus gallus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| brain | - |
Bos taurus | - |
| brain | - |
Lithobates catesbeianus | - |
| brain | - |
Squalus acanthias | - |
| brain | - |
Thunnus thynnus | - |
| heart | - |
Gallus gallus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| heart | - |
Lithobates catesbeianus | - |
| heart | - |
Squalus acanthias | - |
| heart | - |
Thunnus thynnus | - |
| intestinal mucosa | - |
Gallus gallus | - |
| intestinal mucosa | - |
Homo sapiens | - |
| intestinal mucosa | - |
Rattus norvegicus | - |
| intestinal mucosa | - |
Sus scrofa | - |
| intestinal mucosa | - |
Bos taurus | - |
| intestinal mucosa | - |
Lithobates catesbeianus | - |
| intestinal mucosa | - |
Squalus acanthias | - |
| intestinal mucosa | - |
Thunnus thynnus | - |
| kidney | - |
Gallus gallus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Sus scrofa | - |
| kidney | - |
Bos taurus | - |
| kidney | - |
Lithobates catesbeianus | - |
| kidney | - |
Squalus acanthias | - |
| kidney | - |
Thunnus thynnus | - |
| liver | - |
Gallus gallus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
| liver | - |
Lithobates catesbeianus | - |
| liver | - |
Squalus acanthias | - |
| liver | - |
Thunnus thynnus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alanine + H2O + NAD(P)+ | very low activity | Gallus gallus | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Homo sapiens | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Rattus norvegicus | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Sus scrofa | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Bos taurus | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Lithobates catesbeianus | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Auxenochlorella pyrenoidosa | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Squalus acanthias | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Acholeplasma laidlawii | pyruvate + NH3 + NAD(P)H | - |
? | |
| alanine + H2O + NAD(P)+ | very low activity | Thunnus thynnus | pyruvate + NH3 + NAD(P)H | - |
? | |
| homocysteinesulfinate + H2O + NAD(P)+ | - |
Bos taurus | ? | - |
? | |
| L-glutamate + H2O + NAD(P)+ | - |
Gallus gallus | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Homo sapiens | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Rattus norvegicus | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Sus scrofa | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Lithobates catesbeianus | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Auxenochlorella pyrenoidosa | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Squalus acanthias | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Acholeplasma laidlawii | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | - |
Thunnus thynnus | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| L-glutamate + H2O + NAD(P)+ | very low activity with: leucine, alpha-aminobutyrate, valine, isoleucine and methionine | Bos taurus | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| norvaline + H2O + NAD(P)+ | - |
Bos taurus | 2-oxopentanoate + NH3 + NAD(P)H | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
2-oxoglutarate + NH3 + NAD(P)H, liver enzyme | Gallus gallus |
| 7.8 | - |
2-oxoglutarate + NH3 + NAD(P)H, liver enzyme | Homo sapiens |
| 7.8 | - |
2-oxoglutarate + NH3 + NAD(P)H, liver enzyme | Bos taurus |
| 8.3 | 8.6 | glutamate + NAD(P)+ + H2O | Bos taurus |
| 9 | - |
homocysteinesulfinate + NAD(P)+ | Bos taurus |
| 9.5 | - |
norvaline + NAD(P)+ | Bos taurus |
| 9.5 | 10 | alpha-aminobutyrate, valine, norleucine, isoleucine, methionine or alanine + NAD(P)+ | Bos taurus |
| 9.7 | - |
leucine + NAD(P)+ | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Gallus gallus | |
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Rattus norvegicus | |
| NAD+ | - |
Sus scrofa | |
| NAD+ | - |
Bos taurus | |
| NAD+ | - |
Lithobates catesbeianus | |
| NAD+ | - |
Auxenochlorella pyrenoidosa | |
| NAD+ | - |
Squalus acanthias | |
| NAD+ | - |
Acholeplasma laidlawii | |
| NAD+ | - |
Thunnus thynnus | |
| NADH | - |
Gallus gallus | |
| NADH | - |
Homo sapiens | |
| NADH | - |
Rattus norvegicus | |
| NADH | - |
Sus scrofa | |
| NADH | - |
Bos taurus | |
| NADH | - |
Lithobates catesbeianus | |
| NADH | - |
Auxenochlorella pyrenoidosa | |
| NADH | - |
Squalus acanthias | |
| NADH | - |
Acholeplasma laidlawii | |
| NADH | - |
Thunnus thynnus | |
| NADP+ | - |
Gallus gallus | |
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Rattus norvegicus | |
| NADP+ | - |
Sus scrofa | |
| NADP+ | - |
Bos taurus | |
| NADP+ | - |
Lithobates catesbeianus | |
| NADP+ | - |
Auxenochlorella pyrenoidosa | |
| NADP+ | - |
Squalus acanthias | |
| NADP+ | - |
Acholeplasma laidlawii | |
| NADP+ | - |
Thunnus thynnus | |
| NADPH | - |
Gallus gallus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
| NADPH | - |
Sus scrofa | |
| NADPH | - |
Bos taurus | |
| NADPH | - |
Lithobates catesbeianus | |
| NADPH | - |
Auxenochlorella pyrenoidosa | |
| NADPH | - |
Squalus acanthias | |
| NADPH | - |
Acholeplasma laidlawii | |
| NADPH | - |
Thunnus thynnus | |
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