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Literature summary for 1.4.1.3 extracted from

  • Umair, S.; Knight, J.S.; Patchett, M.L.; Bland, R.J.; Simpson, H.V.
    Nucleotide allosteric regulation of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus (2012), Comp. Biochem. Physiol. B, 161, 255-260.
    View publication on PubMed
Search for more literature for 1.4.1.3

Activating Compound

Activating Compound Comment Organism Structure
ADP allosteric regulation, weak stimulation of the deamination reaction and strong activation of the amination reaction Haemonchus contortus
ADP allosteric regulation, weak stimulation of the deamination reaction and strong activation of the amination reaction Teladorsagia circumcincta
ATP allosteric regulation, weak stimulation of the deamination reaction and strong activation of the amination reaction Haemonchus contortus
ATP allosteric regulation, weak stimulation of the deamination reaction and strong activation of the amination reaction Teladorsagia circumcincta

Inhibitors

Inhibitors Comment Organism Structure
GTP allosteric regulation, low inhibition of the deamination reaction and strong inhibition of the amination reaction Haemonchus contortus
GTP allosteric regulation, low inhibition of the deamination reaction and strong inhibition of the amination reaction Teladorsagia circumcincta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + H2O + NAD+ Haemonchus contortus
-
 2-oxoglutarate + NH3 + NADH + H+
-
 r
L-glutamate + H2O + NAD+ Teladorsagia circumcincta
-
 2-oxoglutarate + NH3 + NADH + H+
-
 r
L-glutamate + H2O + NADP+ Haemonchus contortus
-
 2-oxoglutarate + NH3 + NADPH + H+
-
 r
L-glutamate + H2O + NADP+ Teladorsagia circumcincta
-
 2-oxoglutarate + NH3 + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Haemonchus contortus
-
-
-
Teladorsagia circumcincta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme occurs in state L3 and adut nematodes Haemonchus contortus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD+
-
 Haemonchus contortus 2-oxoglutarate + NH3 + NADH + H+
-
 r
L-glutamate + H2O + NAD+
-
 Teladorsagia circumcincta 2-oxoglutarate + NH3 + NADH + H+
-
 r
L-glutamate + H2O + NADP+
-
 Haemonchus contortus 2-oxoglutarate + NH3 + NADPH + H+
-
 r
L-glutamate + H2O + NADP+
-
 Teladorsagia circumcincta 2-oxoglutarate + NH3 + NADPH + H+
-
 r
additional information the glutamate formation activity is 3fold higher than the glutamate deamination activity Haemonchus contortus ?
-
 ?

Synonyms

Synonyms Comment Organism
GDH
-
 Haemonchus contortus
GDH
-
 Teladorsagia circumcincta

Cofactor

Cofactor Comment Organism Structure
additional information GDH is a dual-cofactor GDH Teladorsagia circumcincta
additional information GDH is a dual-cofactor GDH, with activity that is greater with NAD+/NADH than with NADP+/NADPH Haemonchus contortus
NAD+
-
 Haemonchus contortus
NAD+
-
 Teladorsagia circumcincta
NADH
-
 Haemonchus contortus
NADH
-
 Teladorsagia circumcincta
NADP+
-
 Haemonchus contortus
NADP+
-
 Teladorsagia circumcincta
NADPH
-
 Haemonchus contortus
NADPH
-
 Teladorsagia circumcincta

General Information

General Information Comment Organism
physiological function the enzyme provides a pathway for ammonium assimilation Teladorsagia circumcincta
physiological function the enzyme provides a pathway for ammonium assimilation, although the activity for ammonium is low Haemonchus contortus