Literature summary for 1.4.1.4 extracted from

Choi, M.M.; Kim, E.A.; Huh, J.W.; Choi, S.Y.; Cho, S.W.; Yang, S.J.
Small-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells (2008), Biotechnol. Appl. Biochem., 51, 107-110.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell line	BE(2)C neuroblastoma cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
glutamate dehydrogenase	-	Homo sapiens
hGDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
additional information	cofactor specificity not mentioned	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	to test the effect of decreased hGDH expression, small interfering hGDH RNAs are expressed intracellularly in BE(2)C human neuroblastoma cells. hGDH mRNA knockdown is confirmed by immunoblotting and RT-PCR. TUNEL and DNA fragmentation assays 48 h after transfection reveal that inhibition of hGDH expression induces cellular apoptosis and activates phospho-ERK1/2 (phospho-extracellular-signal-regulated kinase 1/2)	Homo sapiens

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Release 2023.1 (January 2023)