Literature summary for 1.4.3.1 extracted from

Katane, M.; Yamada, S.; Kawaguchi, G.; Chinen, M.; Matsumura, M.; Ando, T.; Doi, I.; Nakayama, K.; Kaneko, Y.; Matsuda, S.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Yamaotsu, N.; Hirono, S.; Homma, H.
Identification of novel D-aspartate oxidase inhibitors by in silico screening and their functional and structural characterization in vitro (2015), J. Med. Chem., 58, 7328-7340 .

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli L21(DE3)pLysS cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
1-hydroxy-1H-indole-2-carboxylic acid	-	Homo sapiens
2-amino-5-chlorobenzoic acid	-	Homo sapiens
2-amino-5-methylthiophene-3-carboxylic acid	-	Homo sapiens
2-aminopyridine-3-carboxylic acid	-	Homo sapiens
2-aminopyridine-4-carboxylic acid	-	Homo sapiens
2-hydroxy-6-methylpyridine-3-carboxylic acid	-	Homo sapiens
3-aminobenzoic acid	-	Homo sapiens
3-aminopyridine-2-carboxylic acid	-	Homo sapiens
3-aminopyridine-4-carboxylic acid	-	Homo sapiens
3-hydroxypyridine-2-carboxylic acid	-	Homo sapiens
4-aminopyridine-2-carboxylic acid	-	Homo sapiens
4-aminopyridine-3-carboxylic acid	-	Homo sapiens
4-carbamoylthiophene-2-carboxylic acid	-	Homo sapiens
5-(dimethylamino)pyridine-3-carboxylic acid	-	Homo sapiens
5-(methylamino)pyridine-3-carboxylic acid	-	Homo sapiens
5-(trifluoromethyl)pyridine-3-carboxylic acid	-	Homo sapiens
5-aminonicotinic acid	-	Homo sapiens
5-aminopyridine-2-carboxylic acid	-	Homo sapiens
5-bromopyridine-3-carboxylic acid	-	Homo sapiens
5-chloro-2-hydroxybenzoic acid	-	Homo sapiens
5-chloropyridine-3-carboxylic acid	-	Homo sapiens
5-fluoro-2-hydroxybenzoic acid	-	Homo sapiens
5-fluoropyridine-3-carboxylic acid	-	Homo sapiens
5-hydroxypyridine-3-carboxylic acid	-	Homo sapiens
5-methoxypyridine-3-carboxylic acid	-	Homo sapiens
5-methylpyridine-3-carboxylic acid	-	Homo sapiens
5-nitropyridine-3-carboxylic acid	-	Homo sapiens
5-phenylpyridine-3-carboxylic acid	-	Homo sapiens
5-sulfopyridine-3-carboxylic acid	-	Homo sapiens
6-aminopyridine-2-carboxylic acid	-	Homo sapiens
6-aminopyridine-3-carboxylic acid	-	Homo sapiens
7-hydroxy-4-hydro-1,2,4-triazolo[4,3-a]pyrimidine-6-carboxylic acid	-	Homo sapiens
benzoic acid	-	Homo sapiens
malonic acid	-	Homo sapiens
pyridin-3-amine	-	Homo sapiens
pyridine-3,5-dicarboxylic acid	-	Homo sapiens
pyridine-3-carboxylic acid	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-aspartate + H2O + O2	Homo sapiens	-	oxaloacetate + NH3 + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99489	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-aspartate + H2O + O2	-	Homo sapiens	oxaloacetate + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
DASPO	-	Homo sapiens
DDO	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.0038	-	5-aminonicotinic acid	at pH 8.3 and 37°C	Homo sapiens
0.0151	-	7-hydroxy-4-hydro-1,2,4-triazolo[4,3-a]pyrimidine-6-carboxylic acid	at pH 8.3 and 37°C	Homo sapiens
0.153	-	malonic acid	at pH 8.3 and 37°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0219	-	at pH 8.3 and 37°C	Homo sapiens	5-aminonicotinic acid
0.1	-	IC50 above 0.1 mM, at pH 8.3 and 37°C	Homo sapiens	4-aminopyridine-3-carboxylic acid
0.1	-	IC50 above 0.1 mM, at pH 8.3 and 37°C	Homo sapiens	2-aminopyridine-4-carboxylic acid
0.1	-	IC50 above 0.1 mM, at pH 8.3 and 37°C	Homo sapiens	6-aminopyridine-2-carboxylic acid
0.1	-	IC50 above 0.1 mM, at pH 8.3 and 37°C	Homo sapiens	4-aminopyridine-2-carboxylic acid
1	-	IC50 above 1 mM, at pH 8.3 and 37°C	Homo sapiens	1-hydroxy-1H-indole-2-carboxylic acid
1	-	IC50 above 1 mM, at pH 8.3 and 37°C	Homo sapiens	3-aminopyridine-2-carboxylic acid
1	-	IC50 above 1 mM, at pH 8.3 and 37°C	Homo sapiens	2-aminopyridine-3-carboxylic acid
1	-	IC50 above 1 mM, at pH 8.3 and 37°C	Homo sapiens	5-(dimethylamino)pyridine-3-carboxylic acid
2.364	-	at pH 8.3 and 37°C	Homo sapiens	6-aminopyridine-3-carboxylic acid
2.778	-	at pH 8.3 and 37°C	Homo sapiens	pyridine-3-carboxylic acid
3.351	-	at pH 8.3 and 37°C	Homo sapiens	5-hydroxypyridine-3-carboxylic acid
3.541	-	at pH 8.3 and 37°C	Homo sapiens	5-(methylamino)pyridine-3-carboxylic acid
5	-	IC50 above 5 mM, at pH 8.3 and 37°C	Homo sapiens	4-carbamoylthiophene-2-carboxylic acid
5	-	IC50 above 5 mM, at pH 8.3 and 37°C	Homo sapiens	3-aminopyridine-4-carboxylic acid
5	-	IC50 above 5 mM, at pH 8.3 and 37°C	Homo sapiens	5-phenylpyridine-3-carboxylic acid
5.472	-	at pH 8.3 and 37°C	Homo sapiens	5-methylpyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	3-aminobenzoic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	pyridine-3,5-dicarboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-fluoro-2-hydroxybenzoic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	3-hydroxypyridine-2-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	2-amino-5-chlorobenzoic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-chloro-2-hydroxybenzoic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	2-hydroxy-6-methylpyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	pyridin-3-amine
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-aminopyridine-2-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-methoxypyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-fluoropyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-chloropyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-bromopyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-nitropyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-(trifluoromethyl)pyridine-3-carboxylic acid
10	-	IC50 above 10 mM, at pH 8.3 and 37°C	Homo sapiens	5-sulfopyridine-3-carboxylic acid