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Literature summary for 1.4.3.13 extracted from

  • Rayton, J.K.; Harris, E.D.
    Induction of lysyl oxidase with copper. Properties of an in vitro system (1979), J. Biol. Chem., 254, 621-626.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
actinomycin D
-
Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile irreversible Gallus gallus
cycloheximide inhibits incorporation of lysine and Cu2+ into enzyme, blocks activating process Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ copper metalloenzyme, activation and induction of enzyme synthesis, copper-induced activation maximal at 0.005 mg of copper/ml Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
x * 60000, SDS-PAGE Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity, gel-filtration, ion-exchange Gallus gallus

Reaction

Reaction Comment Organism Reaction ID
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 information about the activation mechanism of copper Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
0.0214 cpm of titrated water formed per h per g wet weight of tissue Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
Gallus gallus peptidyl-L-allysyl-peptide + NH3 + H2O2
-
?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Gallus gallus

Synonyms

Synonyms Comment Organism
lysyl oxidase amine oxidase, oxidative deamination Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Gallus gallus