Cloned (Comment) | Organism |
---|---|
expression analysis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-aminopropionitrile | reduces LOX activity and significantly increases MCP-1 secretion in vascular smooth uscle cells | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | copper-containing enzyme | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Rattus norvegicus |
lysyl oxidase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix. LOX mediates suppression of MCP-1, one of the highly upregulated chemokines, and subsequent inflammatory responses, overview | Rattus norvegicus |