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Literature summary for 1.4.3.13 extracted from

  • Lopez, B.; Querejeta, R.; Gonzalez, A.; Beaumont, J.; Larman, M.; Diez, J.
    Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure (2009), Hypertension, 53, 236-242.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular space
-
Homo sapiens 5615
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart lysyl oxidase protein expression is very scarce in normal hearts, it is highly expressed in failing hearts Homo sapiens
-
myocardium
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
LOX
-
Homo sapiens
lysyl oxidase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ability of torasemide to correct both lysyl oxidase overexpression and enhanced collagen cross-linking down

General Information

General Information Comment Organism
malfunction the enzyme regulates collagen cross-linking, which is increased in heart failure patients compared with healthy hearts. Enzyme overexpression is associated with enhanced collagen cross-linking in the failing human heart. Ability of torasemide to correct both lysyl oxidase overexpression and enhanced collagen cross-linking Homo sapiens
physiological function the enzyme regulates collagen cross-linking Homo sapiens