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Literature summary for 1.4.3.13 extracted from

  • Bondareva, A.; Downey, C.M.; Ayres, F.; Liu, W.; Boyd, S.K.; Hallgrimsson, B.; Jirik, F.R.
    The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells (2009), PLoS ONE, 4, e5620.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.13

Application

Application Comment Organism
medicine LOX inhibition might be useful in metastasis prevention, metastasis model and drug administration study in mice, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-Aminopropionitrile i.e. BAPN, is an irreversible inhibitor of LOX, involved in regulating the metastatic colonization potential of the human breast cancer cell line MDAMB-231 Homo sapiens
beta-aminopropionitrile a specific lysyl oxidase inhibitor, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P28300
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell circulating Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-231-Luc2 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
LOX
-
 Homo sapiens
lysyl oxidase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview. LOX inhibition might be useful in metastasis prevention Homo sapiens
physiological function the extracellular matrix remodeling enzyme has a role in promoting breast cancer cell motility and invasiveness. LOX activity is required during extravasation and/or initial tissue colonization by circulating MDA-MB-231 cells, metastasis model and drug administration study in mice, overview Homo sapiens