Cloned (Comment) | Organism |
---|---|
expressed in Drosophila melanogaster Schneider-2 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N455Q | the mutant protein is not secreted into the medium since the mutation prevents N-glycosylation, so the proteins fail to fold properly and undergo rapid degradation | Homo sapiens |
N644Q | the mutant protein is not secreted into the medium since the mutation prevents N-glycosylation, so the proteins fail to fold properly and undergo rapid degradation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-L-lysyl-peptide + O2 + H2O | Homo sapiens | - |
peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y4K0 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycans at Asn-455 and Asn-644 are essential for proper folding and secretion of the enzyme. The N-glycan at Asn-644 enhances the solubility and stability of the enzyme catalytic domain | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Homo sapiens | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? | |
tropoelastin + H2O + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Loxl2 | - |
Homo sapiens |
lysyl oxidase-like 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
lysyl-tyrosyl quinone | Lys-653 and Tyr-689 are the precursor residues for the lysyl-tyrosyl quinone cofactor of the enzyme | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is highly up-regulated in metastatic breast cancer cells and tissues | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme induces epithelial-to-mesenchymal transition, the first step of metastasis/invasion | Homo sapiens |