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Literature summary for 1.4.3.13 extracted from

  • Zhang, X.; Wang, Q.; Wu, J.; Wang, J.; Shi, Y.; Liu, M.
    Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state (2018), Proc. Natl. Acad. Sci. USA, 115, 3828-3833 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.13

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor-diffusion method at 18°C, crystal structure of the enzyme at 2.4 A resolution Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ copper loading activates hLOXL2 and supports lysyl tyrosylquinone formation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[collagen]-L-lysine + O2 + H2O Homo sapiens the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
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 ?
[elastin]-L-lysine + O2 + H2O Homo sapiens the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix [elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4K0
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[collagen]-L-lysine + O2 + H2O the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix Homo sapiens [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
 ?
[elastin]-L-lysine + O2 + H2O the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix Homo sapiens [elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
Loxl2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix Homo sapiens