Literature summary for 1.4.3.14 extracted from

Pokrovsky, V.S.; Treshalina, H.M.; Lukasheva, E.V.; Sedakova, L.A.; Medentzev, A.G.; Arinbasarova, A.Y.; Berezov, T.T.
Enzymatic properties and anticancer activity of L-lysine alpha-oxidase from Trichoderma cf. aureoviride Rifai BKMF-4268D (2013), Anticancer Drugs, 24, 846-851 .

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Application

Application	Comment	Organism
medicine	the enzyme is an anticancer agent for the treatment of solid tumors in vivo	Trichoderma aureoviride

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0179	-	L-lysine	at pH and °C	Trichoderma aureoviride

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
115000	116000	gel filtration	Trichoderma aureoviride

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-lysine + O2 + H2O	Trichoderma aureoviride	-	6-amino-2-oxohexanoate + NH3 + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Trichoderma aureoviride	-	Rifai BKMF-4268D	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-arginine + O2 + H2O	5.8% activity compared to L-lysine	Trichoderma aureoviride	5-carbamidamido-2-oxopentanoate + NH3 + H2O2	-	?
L-lysine + O2 + H2O	-	Trichoderma aureoviride	6-amino-2-oxohexanoate + NH3 + H2O2	-	?
L-lysine + O2 + H2O	100% activity	Trichoderma aureoviride	6-amino-2-oxohexanoate + NH3 + H2O2	-	?
L-ornithine + O2 + H2O	8.3% activity compared to L-lysine	Trichoderma aureoviride	5-amino-2-oxopentanoic acid + NH3 + H2O2	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 57000-58000, SDS-PAGE	Trichoderma aureoviride

Synonyms

Synonyms	Comment	Organism
L-lysine alpha-oxidase	-	Trichoderma aureoviride

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.8	8	-	Trichoderma aureoviride

pI Value

Organism	Comment	pI Value Maximum	pI Value
Trichoderma aureoviride	isoelectric focusing	-	4.3

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Release 2023.1 (January 2023)