Application | Comment | Organism |
---|---|---|
additional information | LAAO dose-dependently induces aggregation of washed human platelets. It induces tyrosine phosphorylation of a number of platelet proteins including Src kinase, spleen tyrosine kinase, and phospholipase C gamma2. Both H2O2 production and binding to platelet membrane proteins may be involved in its action. The enzyme binds to the platelet membrane to enhance the sensitivity of platelets to H2O2. At the same time, H2O2 released by the enzyme activates platelets by an unknown mechanism | Naja atra |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | inhibits platelet aggregation induced by LAAO | Naja atra | |
EMD 132338 | inhibits platelet aggregation induced by LAAO | Naja atra | |
additional information | LAAO has no activity on platelets in platelet-rich plasma. Catalase inhibits the platelet aggregation and platelet protein phosphorylation induced by LAAO | Naja atra |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Naja atra | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by cation ion exchange chromatography, gel filtration and anion ion exchange chromatography, to homogeneity | Naja atra |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Naja atra | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-leucine + H2O + O2 | - |
Naja atra | 4-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LAAO | - |
Naja atra |