Any feedback?
Literature summary for 1.4.3.2 extracted from
- Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory (2018), Sci. Rep., 8, 11073 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O09046 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LAO1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | compared to wild-type mice, LAO1 KO mice exhibit impaired fear learning and memory function in a passive avoidance test, coinciding with significantly reduced hippocampal acetylcholine levels, while treatment with donepezil, a reversible acetylcholine esterase inhibitor, inhibits this reduction. Knocking out LAO1 affects amino acid metabolism (mainly of phenylalanine) in the hippocampus. Phenylalanine levels are elevated in LAO1 KO mice, while phenylpyruvic acid levels are reduced. Knocking out LAO1 decreases hippocampal mRNA levels of pyruvate kinase, which is inhibited by phenylalanine | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
